Pharmacokinetics and toxicokinetics are pivotal components of pharmacology and toxicology. We offer a comprehensive consultancy service to interpret and elaborate scientific results for a better understanding of drug or chemical distribution.
The consultancy service offers support and assistance for several aspects of pharmacokinetics/toxicokinetics and can be offered as part of an integrated program with our in vitro and in silico approaches. Our main areas of activity focus on supporting study design and protocol optimisation for bioequivalence, metabolism, bioavailability, pharmacogenetics, novel formulations, drug and food interaction studies. Additionally we provide interpretation of pharmacokinetic and toxicokinetic data to support our customers in drug/compound development processes or definition of follow-up studies. We are committed to support our customer in the design and optimisation of clinical studies as well as a better understanding of the drug/compound distribution and toxicity.
Our team has been actively involved in the definition, design and analysis of numerous clinical studies for the investigation of pharmacogenetics (Olagunju A et al. Clin Pharmacol Ther. 2015 Mar;97(3):298-306.; Siccardi et al. Clin Infect Dis. 2008 Nov 1;47(9):1222-5.; Siccardi et al. Pharmacogenet Genomics. 2010 Dec;20(12):759-65.), drug-drug interactions (Scarsi et al. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19484.) and special populations (Olagunju A, et al. Clin Infect Dis. 2015 Aug 1;61(3):453-63.; Marzolini C, et al AIDS. 2015 Jan 14;29(2):193-200.)